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Target
Protein Wnt-3a
Ligand
BDBM77198
Substrate
n/a
IC50
282±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM77198
Synonyms:
5,6-dimethyl-4-[4-[2-(4-methylphenoxy)ethyl]-1-piperazinyl]thieno[2,3-d]pyrimidine | 5,6-dimethyl-4-[4-[2-(4-methylphenoxy)ethyl]piperazin-1-yl]thieno[2,3-d]pyrimidine | 5,6-dimethyl-4-[4-[2-(4-methylphenoxy)ethyl]piperazino]thieno[2,3-d]pyrimidine | 5,6-dimethyl-4-{4-[2-(4-methylphenoxy)ethyl]-1-piperazinyl}thieno[2,3-d]pyrimidine | MLS000537743 | SMR000143981 | cid_1999904
Type:
Small organic molecule
Emp. Form.:
C21H26N4OS
Mol. Mass.:
382.522
SMILES:
Cc1sc2ncnc(N3CCN(CCOc4ccc(C)cc4)CC3)c2c1C
Structure:
Search PDB for entries with ligand similarity: