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Target
Protein Wnt-3a
Ligand
BDBM89255
Substrate
n/a
IC50
1140±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM89255
Synonyms:
4-[4-(4-methoxyphenyl)-1-piperazinyl]-5H-pyrimido[5,4-b]indole | 4-[4-(4-methoxyphenyl)piperazin-1-yl]-5H-pyrimido[5,4-b]indole | 4-[4-(4-methoxyphenyl)piperazino]-5H-pyrimid[5,4-b]indole | 4-[4-(4-methoxyphenyl)piperazino]-5H-pyrimido[5,4-b]indole | MLS000539554 | SMR000125212 | cid_1475855
Type:
Small organic molecule
Emp. Form.:
C21H21N5O
Mol. Mass.:
359.4243
SMILES:
COc1ccc(cc1)N1CCN(CC1)c1ncnc2c3ccccc3[nH]c12
Structure:
Search PDB for entries with ligand similarity: