Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM89401
Substrate
n/a
IC50
338±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM89401
Synonyms:
MLS001126732 | SMR000657962 | [3-(3-hydroxypropyl)-1-piperidinyl]-[5-(5-isoquinolinyloxymethyl)-3-isoxazolyl]methanone | [3-(3-hydroxypropyl)piperidin-1-yl]-[5-(isoquinolin-5-yloxymethyl)-1,2-oxazol-3-yl]methanone | [3-(3-hydroxypropyl)piperidino]-[5-(5-isoquinolyloxymethyl)isoxazol-3-yl]methanone | [5-(isoquinolin-5-yloxymethyl)-1,2-oxazol-3-yl]-[3-(3-oxidanylpropyl)piperidin-1-yl]methanone | cid_24792035
Type:
Small organic molecule
Emp. Form.:
C22H25N3O4
Mol. Mass.:
395.4516
SMILES:
OCCCC1CCCN(C1)C(=O)c1cc(COc2cccc3cnccc23)on1
Structure:
Search PDB for entries with ligand similarity: