Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM89406
Substrate
n/a
IC50
444±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM89406
Synonyms:
1-(4-Diethylsulfamoyl-benzenesulfonyl)-piperidine-3-carboxylic acid cyclopropylamide | MLS001220455 | N-cyclopropyl-1-[4-(diethylsulfamoyl)phenyl]sulfonyl-3-piperidinecarboxamide | N-cyclopropyl-1-[4-(diethylsulfamoyl)phenyl]sulfonyl-nipecotamide | N-cyclopropyl-1-[4-(diethylsulfamoyl)phenyl]sulfonyl-piperidine-3-carboxamide | N-cyclopropyl-1-[4-(diethylsulfamoyl)phenyl]sulfonylpiperidine-3-carboxamide | SMR000601324 | cid_3214767
Type:
Small organic molecule
Emp. Form.:
C19H29N3O5S2
Mol. Mass.:
443.581
SMILES:
CCN(CC)S(=O)(=O)c1ccc(cc1)S(=O)(=O)N1CCCC(C1)C(=O)NC1CC1
Structure:
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