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Target
Protein Wnt-3a
Ligand
BDBM89451
Substrate
n/a
IC50
1160±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM89451
Synonyms:
3-amino-N-(4-methoxyphenyl)-4-(4-morpholinyl)benzenesulfonamide | 3-amino-N-(4-methoxyphenyl)-4-morpholin-4-ylbenzenesulfonamide | 3-amino-N-(4-methoxyphenyl)-4-morpholino-benzenesulfonamide | 3-azanyl-N-(4-methoxyphenyl)-4-morpholin-4-yl-benzenesulfonamide | MLS002166959 | SMR001249295 | cid_3292313
Type:
Small organic molecule
Emp. Form.:
C17H21N3O4S
Mol. Mass.:
363.431
SMILES:
COc1ccc(NS(=O)(=O)c2ccc(N3CCOCC3)c(N)c2)cc1
Structure:
Search PDB for entries with ligand similarity: