Reaction Details Report a problem with these data
Target
Endothelial PAS domain-containing protein 1
Ligand
BDBM94015
Substrate
n/a
IC50
913±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS identification of HIF-2a Inhibitors in a luminesence assay PubChem Bioassay (2012)[AID] 
Target
Name:
Endothelial PAS domain-containing protein 1
Synonyms:
BHLHE73 | EPAS1 | EPAS1_HUMAN | HIF2A | MOP2 | PASD2 | endothelial PAS domain-containing protein 1
Type:
PROTEIN
Mol. Mass.:
96453.58
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1506501
Residue:
870
Sequence:
MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQNFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCSTPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDFQLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPEHRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTEFLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQDLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHLPLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELTRYDCEVNVPVLGSSTLLQGGDLLRALDQAT
  
Inhibitor
Name:
BDBM94015
Synonyms:
2-[4-(4-pyridin-2-ylpyrimidin-2-yl)phenoxy]acetic acid | 2-[4-(4-pyridin-2-ylpyrimidin-2-yl)phenoxy]ethanoic acid | 2-[4-[4-(2-pyridinyl)-2-pyrimidinyl]phenoxy]acetic acid | 2-[4-[4-(2-pyridyl)pyrimidin-2-yl]phenoxy]acetic acid | 2-{4-[4-(2-pyridinyl)-2-pyrimidinyl]phenoxy}acetic acid | MLS000755352 | SMR000338229 | cid_2767852
Type:
Small organic molecule
Emp. Form.:
C17H13N3O3
Mol. Mass.:
307.3034
SMILES:
OC(=O)COc1ccc(cc1)-c1nccc(n1)-c1ccccn1
Structure:
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