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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89949
Substrate
n/a
IC50
2580±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89949
Synonyms:
3,3,3-trifluoro-2-[(5-nosylthiazol-2-yl)amino]-2-(p-anisoylamino)propionic acid methyl ester | 3,3,3-trifluoro-2-[[(4-methoxyphenyl)-oxomethyl]amino]-2-[[5-(4-nitrophenyl)sulfonyl-2-thiazolyl]amino]propanoic acid methyl ester | MLS000325345 | SMR000163417 | cid_5103080 | methyl 3,3,3-trifluoro-2-[(4-methoxybenzoyl)amino]-2-[[5-(4-nitrophenyl)sulfonyl-1,3-thiazol-2-yl]amino]propanoate | methyl 3,3,3-trifluoro-2-{[5-({4-nitrophenyl}sulfonyl)-1,3-thiazol-2-yl]amino}-2-[(4-methoxybenzoyl)amino]propanoate | methyl 3,3,3-tris(fluoranyl)-2-[(4-methoxyphenyl)carbonylamino]-2-[[5-(4-nitrophenyl)sulfonyl-1,3-thiazol-2-yl]amino]propanoate
Type:
Small organic molecule
Emp. Form.:
C21H17F3N4O8S2
Mol. Mass.:
574.507
SMILES:
COC(=O)C(NC(=O)c1ccc(OC)cc1)(Nc1ncc(s1)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O)C(F)(F)F
Structure:
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