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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90766
Substrate
n/a
IC50
5130±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90766
Synonyms:
1-[(2-benzyl-5-tert-butyl-pyrazole-3-carbonyl)amino]-3-(3-chlorophenyl)urea | 1-[(2-benzyl-5-tert-butylpyrazole-3-carbonyl)amino]-3-(3-chlorophenyl)urea | 1-[[5-tert-butyl-2-(phenylmethyl)pyrazol-3-yl]carbonylamino]-3-(3-chlorophenyl)urea | 1-[[[5-tert-butyl-2-(phenylmethyl)-3-pyrazolyl]-oxomethyl]amino]-3-(3-chlorophenyl)urea | MLS000834880 | N1-(3-chlorophenyl)-2-{[1-benzyl-3-(tert-butyl)-1H-pyrazol-5-yl]carbonyl}hydrazine-1-carboxamide | SMR000461396 | cid_2744568
Type:
Small organic molecule
Emp. Form.:
C22H24ClN5O2
Mol. Mass.:
425.911
SMILES:
CC(C)(C)c1cc(C(=O)NNC(=O)Nc2cccc(Cl)c2)n(Cc2ccccc2)n1
Structure:
Search PDB for entries with ligand similarity: