Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90655
Substrate
n/a
IC50
340±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90655
Synonyms:
2-(3-carbethoxy-2-phenyl-benzofuran-5-yl)oxypropionic acid;ethanol | 5-(1-Carboxy-ethoxy)-2-phenyl-benzofuran-3-carboxylic acid ethyl ester | MLS000777286 | SMR000413680 | cid_16681773 | ethanol;2-[(3-ethoxycarbonyl-2-phenyl-1-benzofuran-5-yl)oxy]propanoic acid | ethanol;2-[(3-ethoxycarbonyl-2-phenyl-5-benzofuranyl)oxy]propanoic acid
Type:
Small organic molecule
Emp. Form.:
C20H18O6
Mol. Mass.:
354.3533
SMILES:
CCOC(=O)c1c(oc2ccc(OC(C)C(O)=O)cc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: