Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89703
Substrate
n/a
IC50
1870±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89703
Synonyms:
4,5-dimethoxy-2-[(5-methyl-3-phenyl-isoxazole-4-carbonyl)amino]benzoic acid methyl ester | 4,5-dimethoxy-2-[[(5-methyl-3-phenyl-4-isoxazolyl)-oxomethyl]amino]benzoic acid methyl ester | MLS000051717 | SMR000080551 | cid_1246353 | methyl 4,5-dimethoxy-2-[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonylamino]benzoate | methyl 4,5-dimethoxy-2-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]benzoate | methyl 4,5-dimethoxy-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}benzoate
Type:
Small organic molecule
Emp. Form.:
C21H20N2O6
Mol. Mass.:
396.3933
SMILES:
COC(=O)c1cc(OC)c(OC)cc1NC(=O)c1c(C)onc1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: