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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90198
Substrate
n/a
IC50
4930±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90198
Synonyms:
1-benzyl-2-(4-methoxyphenyl)-3-[(1-phenylethylidene)amino]-4-imidazolidinone | 1-benzyl-2-(4-methoxyphenyl)-3-[(E)-1-phenylethylideneamino]-4-imidazolidinone | 1-benzyl-2-(4-methoxyphenyl)-3-[(E)-1-phenylethylideneamino]imidazolidin-4-one | 2-(4-methoxyphenyl)-3-[(E)-1-phenylethylideneamino]-1-(phenylmethyl)-4-imidazolidinone | 2-(4-methoxyphenyl)-3-[(E)-1-phenylethylideneamino]-1-(phenylmethyl)imidazolidin-4-one | MLS000700191 | SMR000225561 | cid_9566991
Type:
Small organic molecule
Emp. Form.:
C25H25N3O2
Mol. Mass.:
399.4849
SMILES:
COc1ccc(cc1)C1N(Cc2ccccc2)CC(=O)N1N=C(C)c1ccccc1 |w:21.23|
Structure:
Search PDB for entries with ligand similarity: