Reaction Details
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Corticotropin-releasing factor-binding protein
Ligand
BDBM53804
Substrate
n/a
IC50
1470±n/a nM
Citation
PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
Inhibitor
Name:
BDBM53804
Synonyms:
4-({2-[(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl]phenoxy}methyl)benzoic acid | 4-[[2-[(1,3-diketoindan-2-ylidene)methyl]phenoxy]methyl]benzoic acid | 4-[[2-[(1,3-dioxo-2-indenylidene)methyl]phenoxy]methyl]benzoic acid | 4-[[2-[(1,3-dioxoinden-2-ylidene)methyl]phenoxy]methyl]benzoic acid | 4-[[2-[[1,3-bis(oxidanylidene)inden-2-ylidene]methyl]phenoxy]methyl]benzoic acid | MLS000574767 | SMR000196200 | cid_1209375
Type:
Small organic molecule
Emp. Form.:
C24H16O5
Mol. Mass.:
384.3808
SMILES:
[#8]-[#6](=O)-c1ccc(-[#6]-[#8]-c2ccccc2\[#6]=[#6]-2\[#6](=O)-c3ccccc3-[#6]-2=O)cc1
Structure:
