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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM69010
Substrate
n/a
IC50
2570±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM69010
Synonyms:
6-[(3-methylbenzyl)thio]-3-(2-thienyl)-[1,2,4]triazolo[4,3-b]pyridazine | 6-[(3-methylphenyl)methylsulfanyl]-3-thiophen-2-yl-[1,2,4]triazolo[4,3-b]pyridazine | 6-[(3-methylphenyl)methylthio]-3-thiophen-2-yl-[1,2,4]triazolo[4,3-b]pyridazine | MLS000724818 | SMR000236998 | cid_7190401
Type:
Small organic molecule
Emp. Form.:
C17H14N4S2
Mol. Mass.:
338.45
SMILES:
Cc1cccc(CSc2ccc3nnc(-c4cccs4)n3n2)c1
Structure:
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