Reaction Details Report a problem with these data
Target
Perilipin-1
Ligand
BDBM47853
Substrate
n/a
IC50
683.8±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) PubChem Bioassay (2012)[AID] 
Target
Name:
Perilipin-1
Synonyms:
PERI | PLIN | PLIN1 | PLIN1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55988.69
Organism:
Homo sapiens (Human)
Description:
gi_223718203
Residue:
522
Sequence:
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLALGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLSSLAQWGASVAMQAVSRRRSEVRVPWLHSLAAAQEEDHEDQTDTEGEDTEEEEELETEENKFSEVAALPGPRGLLGGVAHTLQKTLQTTISAVTWAPAAVLGMAGRVLHLTPAPAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPPAEVERREAERRASGAPSAGPEPAPRLAQPRRSLRSAQSPGAPPGPGLEDEVATPAAPRPGFPAVPREKPKRRVSDSFFRPSVMEPILGRTHYSQLRKKS
  
Inhibitor
Name:
BDBM47853
Synonyms:
2-furancarboxylic acid [4-bromo-2-[(E)-3-(4-methylphenyl)-1-oxoprop-2-enyl]phenyl] ester | 4-bromo-2-[3-(4-methylphenyl)acryloyl]phenyl 2-furoate | MLS000575689 | SMR000196723 | [4-bromanyl-2-[(E)-3-(4-methylphenyl)prop-2-enoyl]phenyl] furan-2-carboxylate | [4-bromo-2-[(E)-3-(4-methylphenyl)prop-2-enoyl]phenyl] furan-2-carboxylate | cid_5735038 | furan-2-carboxylic acid [4-bromo-2-[(E)-3-(p-tolyl)acryloyl]phenyl] ester
Type:
Small organic molecule
Emp. Form.:
C21H15BrO4
Mol. Mass.:
411.245
SMILES:
Cc1ccc(\C=C\C(=O)c2cc(Br)ccc2OC(=O)c2ccco2)cc1
Structure:
Search PDB for entries with ligand similarity: