Target
Xylosyl- and glucuronyltransferase LARGE1
Ligand
BDBM94646
Substrate
n/a
EC50
34500±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of alpha dystroglycan glycosylation PubChem Bioassay (2012)[AID] 
Target
Name:
Xylosyl- and glucuronyltransferase LARGE1
Synonyms:
KIAA0609 | LARG1_HUMAN | LARGE | LARGE1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
88079.63
Organism:
Homo sapiens (Human)
Description:
gi_47678551
Residue:
756
Sequence:
MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS
  
Inhibitor
Name:
BDBM94646
Synonyms:
1-(4-fluorophenyl)-2-(2-imino-3-methyl-1-benzimidazolyl)ethanone;hydrobromide | 1-(4-fluorophenyl)-2-(2-imino-3-methyl-benzimidazol-1-yl)ethanone;hydrobromide | 1-(4-fluorophenyl)-2-(2-imino-3-methylbenzimidazol-1-yl)ethanone;hydrobromide | 2-(2-azanylidene-3-methyl-benzimidazol-1-yl)-1-(4-fluorophenyl)ethanone;hydrobromide | MLS-0322108.0001 | cid_24761194
Type:
Small organic molecule
Emp. Form.:
C16H14FN3O
Mol. Mass.:
283.3003
SMILES:
Cn1c2ccccc2n(CC(=O)c2ccc(F)cc2)c1=N
Structure:
Search PDB for entries with ligand similarity: