Reaction Details Report a problem with these data
Target
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Ligand
BDBM94656
Substrate
n/a
IC50
38487±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Synonyms:
ASAP1 | ASAP1_HUMAN | DDEF1 | KIAA1249 | PAG2 | arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
125507.11
Organism:
Homo sapiens (Human)
Description:
Q9ULH1
Residue:
1129
Sequence:
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
  
Inhibitor
Name:
BDBM94656
Synonyms:
2-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-keto-pyridazin-1-yl]-N-[4-(tetrazol-1-yl)phenyl]acetamide | 2-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-oxidanylidene-pyridazin-1-yl]-N-[4-(1,2,3,4-tetrazol-1-yl)phenyl]ethanamide | 2-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-oxo-1-pyridazinyl]-N-[4-(1-tetrazolyl)phenyl]acetamide | 2-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-oxopyridazin-1-yl]-N-[4-(tetrazol-1-yl)phenyl]acetamide | MLS000856758 | SMR000278703 | cid_3224510
Type:
Small organic molecule
Emp. Form.:
C21H17N7O4
Mol. Mass.:
431.4042
SMILES:
O=C(Cn1nc(ccc1=O)-c1ccc2OCCOc2c1)Nc1ccc(cc1)-n1cnnn1
Structure:
Search PDB for entries with ligand similarity: