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Target
Sentrin-specific protease 1
Ligand
BDBM89947
Substrate
n/a
IC50
9920±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM89947
Synonyms:
1-(dimethylamino)-3-(2,3-dipyridin-2-ylquinoxalin-6-yl)thiourea | 1-[2,3-bis(2-pyridinyl)-6-quinoxalinyl]-3-(dimethylamino)thiourea | 1-[2,3-bis(2-pyridyl)quinoxalin-6-yl]-3-(dimethylamino)thiourea | MLS000537509 | N-[2,3-di(2-pyridinyl)-6-quinoxalinyl]-2,2-dimethylhydrazinecarbothioamide | SMR000163821 | cid_1209213
Type:
Small organic molecule
Emp. Form.:
C21H19N7S
Mol. Mass.:
401.487
SMILES:
CN(C)NC(=S)Nc1ccc2nc(-c3ccccn3)c(nc2c1)-c1ccccn1
Structure:
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