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Target
Sentrin-specific protease 1
Ligand
BDBM72772
Substrate
n/a
IC50
13800±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM72772
Synonyms:
3,6-bis(azanyl)-4-methylsulfanyl-2-(phenylcarbonyl)thieno[2,3-b]pyridine-5-carbonitrile | 3,6-diamino-2-benzoyl-4-(methylthio)-5-thieno[2,3-b]pyridinecarbonitrile | 3,6-diamino-2-benzoyl-4-(methylthio)thieno[2,3-b]pyridine-5-carbonitrile | 3,6-diamino-2-benzoyl-4-methylsulfanylthieno[2,3-b]pyridine-5-carbonitrile | MLS000861448 | SMR000460232 | cid_2727621
Type:
Small organic molecule
Emp. Form.:
C16H12N4OS2
Mol. Mass.:
340.423
SMILES:
CSc1c(C#N)c(N)nc2sc(C(=O)c3ccccc3)c(N)c12
Structure:
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