Reaction Details
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Sentrin-specific protease 1
Ligand
BDBM72881
Substrate
n/a
IC50
10100±n/a nM
Citation
PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
Inhibitor
Name:
BDBM72881
Synonyms:
(2Z)-2-[(4-nitrophenyl)methylidene]-6-oxidanyl-1-benzofuran-3-one | (2Z)-6-hydroxy-2-(4-nitrobenzylidene)coumaran-3-one | (2Z)-6-hydroxy-2-[(4-nitrophenyl)methylidene]-1-benzofuran-3-one | (2Z)-6-hydroxy-2-[(4-nitrophenyl)methylidene]-3-benzofuranone | MLS001215098 | SMR000543182 | cid_940606
Type:
Small organic molecule
Emp. Form.:
C15H9NO5
Mol. Mass.:
283.2357
SMILES:
Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(cc1)[N+]([O-])=O
Structure:
