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Target
Sentrin-specific protease 1
Ligand
BDBM91282
Substrate
n/a
IC50
13200±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM91282
Synonyms:
6-(4-morpholinyl)-9,10,10-trioxo-N-prop-2-enyl-1-thioxanthenecarboxamide | 6-morpholin-4-yl-9,10,10-trioxo-N-prop-2-enylthioxanthene-1-carboxamide | 6-morpholin-4-yl-9,10,10-tris(oxidanylidene)-N-prop-2-enyl-thioxanthene-1-carboxamide | MLS002472301 | N-allyl-9,10,10-triketo-6-morpholino-thioxanthene-1-carboxamide | SMR001395452 | cid_44144218
Type:
Small organic molecule
Emp. Form.:
C21H20N2O5S
Mol. Mass.:
412.459
SMILES:
C=CCNC(=O)c1cccc2c1C(=O)c1ccc(cc1S2(=O)=O)N1CCOCC1
Structure:
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