Reaction Details Report a problem with these data
Target
Sentrin-specific protease 1
Ligand
BDBM94860
Substrate
n/a
IC50
6060±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94860
Synonyms:
(4E)-4-[(2-fluoren-9-ylidenehydrazinyl)methylidene]-3-hydroxycyclohexa-2,5-dien-1-one | (4E)-4-[(2-fluoren-9-ylidenehydrazinyl)methylidene]-3-oxidanyl-cyclohexa-2,5-dien-1-one | (4E)-4-[(N'-fluoren-9-ylidenehydrazino)methylene]-3-hydroxy-cyclohexa-2,5-dien-1-one | (4E)-4-[[2-(9-fluorenylidene)hydrazinyl]methylidene]-3-hydroxy-1-cyclohexa-2,5-dienone | MLS002707051 | SMR001574447 | cid_5403226
Type:
Small organic molecule
Emp. Form.:
C20H14N2O2
Mol. Mass.:
314.3374
SMILES:
[#8]-c1ccc(-[#6]=[#7]\[#7]=[#6]-2\c3ccccc3-c3ccccc-23)c(-[#8])c1 |w:6.6|
Structure:
Search PDB for entries with ligand similarity: