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Target
Sentrin-specific protease 1
Ligand
BDBM94865
Substrate
n/a
IC50
12200±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94865
Synonyms:
MLS003124309 | N-[6-[4-(4-methyl-1-piperazinyl)phenyl]-3-phenyl-8-imidazo[1,2-a]pyridinyl]acetamide | N-[6-[4-(4-methylpiperazin-1-yl)phenyl]-3-phenyl-imidazo[1,2-a]pyridin-8-yl]ethanamide | N-[6-[4-(4-methylpiperazin-1-yl)phenyl]-3-phenylimidazo[1,2-a]pyridin-8-yl]acetamide | N-[6-[4-(4-methylpiperazino)phenyl]-3-phenyl-imidazo[1,2-a]pyridin-8-yl]acetamide | SMR001292858 | cid_49791256
Type:
Small organic molecule
Emp. Form.:
C26H27N5O
Mol. Mass.:
425.5255
SMILES:
CN1CCN(CC1)c1ccc(cc1)-c1cc(NC(C)=O)c2ncc(-c3ccccc3)n2c1
Structure:
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