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Target
Sentrin-specific protease 1
Ligand
BDBM94872
Substrate
n/a
IC50
1930±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94872
Synonyms:
(2E)-2-[1-(2,6-dimethylphenyl)-2H-1,2,3,4-tetrazol-5-ylidene]benzo[g]quinoxalin-3-one | (2E)-2-[1-(2,6-dimethylphenyl)-2H-tetrazol-5-ylidene]-3-benzo[g]quinoxalinone | (2E)-2-[1-(2,6-dimethylphenyl)-2H-tetrazol-5-ylidene]benzo[g]quinoxalin-3-one | MLS003468545 | SMR002134470 | cid_53299664
Type:
Small organic molecule
Emp. Form.:
C21H16N6O
Mol. Mass.:
368.3913
SMILES:
Cc1cccc(C)c1-n1nnnc1-c1nc2cc3ccccc3cc2[nH]c1=O |(14.4,2.93,;12.86,2.98,;12.13,4.34,;10.59,4.39,;9.78,3.08,;10.51,1.72,;9.7,.41,;12.05,1.67,;12.78,.32,;14.28,.64,;15.06,-.69,;14.03,-1.84,;12.62,-1.22,;11.29,-1.99,;9.9,-1.2,;8.52,-2.02,;7.19,-1.25,;5.85,-2.02,;4.48,-1.2,;3.08,-1.99,;3.08,-3.6,;4.48,-4.39,;5.85,-3.56,;7.19,-4.33,;8.52,-3.56,;9.9,-4.39,;11.29,-3.6,;12.62,-4.37,)|
Structure:
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