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Target
Sentrin-specific protease 1
Ligand
BDBM94772
Substrate
n/a
IC50
35900±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94772
Synonyms:
(3-Amino-7-methyl-thieno[2,3-b]quinolin-2-yl)-morpholin-4-yl-methanone | (3-amino-7-methyl-2-thieno[2,3-b]quinolinyl)-(4-morpholinyl)methanone | (3-amino-7-methyl-thieno[2,3-b]quinolin-2-yl)-morpholino-methanone | (3-amino-7-methylthieno[2,3-b]quinolin-2-yl)-morpholin-4-ylmethanone | (3-azanyl-7-methyl-thieno[2,3-b]quinolin-2-yl)-morpholin-4-yl-methanone | MLS000029763 | SMR000001653 | cid_652702
Type:
Small organic molecule
Emp. Form.:
C17H17N3O2S
Mol. Mass.:
327.401
SMILES:
Cc1ccc2cc3c(N)c(sc3nc2c1)C(=O)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: