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Target
Sentrin-specific protease 1
Ligand
BDBM94786
Substrate
n/a
IC50
10100±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94786
Synonyms:
(3Z)-N-[(E)-[4-(dimethylamino)benzylidene]amino]-2-keto-3-spiro[2,4-dihydroisoquinoline-3,1'-cyclopentane]-1-ylidene-propionamide | (3Z)-N-[(E)-[4-(dimethylamino)phenyl]methylideneamino]-2-oxidanylidene-3-spiro[2,4-dihydroisoquinoline-3,1'-cyclopentane]-1-ylidene-propanamide | (3Z)-N-[(E)-[4-(dimethylamino)phenyl]methylideneamino]-2-oxo-3-(1-spiro[2,4-dihydroisoquinoline-3,1'-cyclopentane]ylidene)propanamide | (3Z)-N-[(E)-[4-(dimethylamino)phenyl]methylideneamino]-2-oxo-3-spiro[2,4-dihydroisoquinoline-3,1'-cyclopentane]-1-ylidenepropanamide | MLS000589038 | SMR000219661 | cid_6880338
Type:
Small organic molecule
Emp. Form.:
C25H28N4O2
Mol. Mass.:
416.5154
SMILES:
CN(C)c1ccc(C=NNC(=O)C(=O)CC2=NC3(CCCC3)Cc3ccccc23)cc1 |w:8.8,t:15|
Structure:
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