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Target
Sentrin-specific protease 1
Ligand
BDBM51033
Substrate
n/a
IC50
24400±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM51033
Synonyms:
6-(4-Isopropoxy-3-methoxy-benzyl)-9-methoxy-6H-indolo[2,3-b]quinoxaline | 6-(4-isopropoxy-3-methoxy-benzyl)-9-methoxy-indolo[3,2-b]quinoxaline | 9-methoxy-6-[(3-methoxy-4-propan-2-yloxy-phenyl)methyl]indolo[3,2-b]quinoxaline | 9-methoxy-6-[(3-methoxy-4-propan-2-yloxyphenyl)methyl]indolo[3,2-b]quinoxaline | MLS000331758 | SMR000220815 | cid_1828599
Type:
Small organic molecule
Emp. Form.:
C26H25N3O3
Mol. Mass.:
427.495
SMILES:
COc1ccc2n(Cc3ccc(OC(C)C)c(OC)c3)c3nc4ccccc4nc3c2c1
Structure:
Search PDB for entries with ligand similarity: