Reaction Details
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Sentrin-specific protease 1
Ligand
BDBM63822
Substrate
n/a
IC50
23900±n/a nM
Citation
PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
Inhibitor
Name:
BDBM63822
Synonyms:
2H-Isoindole-2-acetic acid, .alpha.- (3-amino-3-oxopropyl)-1, 3-dihydro-5-hydroxy-1,3-dioxo- | 5-amino-2-(5-hydroxy-1,3-diketo-isoindolin-2-yl)-5-keto-valeric acid | 5-amino-2-(5-hydroxy-1,3-dioxo-2-isoindolyl)-5-oxopentanoic acid | 5-amino-2-(5-hydroxy-1,3-dioxoisoindol-2-yl)-5-oxopentanoic acid | 5-azanyl-2-[5-oxidanyl-1,3-bis(oxidanylidene)isoindol-2-yl]-5-oxidanylidene-pentanoic acid | MLS000736849 | SMR000528349 | cid_254339
Type:
Small organic molecule
Emp. Form.:
C13H12N2O6
Mol. Mass.:
292.2442
SMILES:
NC(=O)CCC(N1C(=O)c2ccc(O)cc2C1=O)C(O)=O
Structure:
