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Target
Sentrin-specific protease 1
Ligand
BDBM94861
Substrate
n/a
IC50
12500±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94861
Synonyms:
MLS002707326 | N-(3-chloranyl-9-hydroxyimino-7-nitro-fluoren-2-yl)-2,2,2-tris(fluoranyl)ethanamide | N-(3-chloro-9-hydroximino-7-nitro-fluoren-2-yl)-2,2,2-trifluoro-acetamide | N-(3-chloro-9-hydroxyimino-7-nitro-2-fluorenyl)-2,2,2-trifluoroacetamide | N-(3-chloro-9-hydroxyimino-7-nitrofluoren-2-yl)-2,2,2-trifluoroacetamide | SMR001574718 | cid_4202928
Type:
Small organic molecule
Emp. Form.:
C15H7ClF3N3O4
Mol. Mass.:
385.682
SMILES:
[O-][N+](=O)c1ccc2c(c1)[c-](N=[OH+])c1cc(NC(=O)C(F)(F)F)c(Cl)cc21
Structure:
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