Target
Hepatocyte nuclear factor 4-alpha
Ligand
BDBM83788
Substrate
n/a
IC50
1588±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization PubChem Bioassay (2012)[AID] 
Target
Name:
Hepatocyte nuclear factor 4-alpha
Synonyms:
HNF4 | HNF4A | HNF4A_HUMAN | NR2A1 | TCF14 | hepatocyte nuclear factor 4-alpha isoform b
Type:
PROTEIN
Mol. Mass.:
52790.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_606516
Residue:
474
Sequence:
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
  
Inhibitor
Name:
BDBM83788
Synonyms:
(5Z)-1-benzyl-5-[(E)-3-(2-furyl)prop-2-enylidene]barbituric acid | (5Z)-1-benzyl-5-[(E)-3-(furan-2-yl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione | (5Z)-5-[(E)-3-(2-furanyl)prop-2-enylidene]-1-(phenylmethyl)-1,3-diazinane-2,4,6-trione | (5Z)-5-[(E)-3-(furan-2-yl)prop-2-enylidene]-1-(phenylmethyl)-1,3-diazinane-2,4,6-trione | 1-benzyl-5-[3-(2-furyl)-2-propen-1-ylidene]-2,4,6(1H,3H,5H)-pyrimidinetrione | MLS000680483 | SMR000268660 | cid_1908237
Type:
Small organic molecule
Emp. Form.:
C18H14N2O4
Mol. Mass.:
322.3148
SMILES:
O=C1NC(=O)\C(=C\C=C\c2ccco2)C(=O)N1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: