Reaction Details Report a problem with these data
Target
Hepatocyte nuclear factor 4-alpha
Ligand
BDBM94587
Substrate
n/a
IC50
2540±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization PubChem Bioassay (2012)[AID] 
Target
Name:
Hepatocyte nuclear factor 4-alpha
Synonyms:
HNF4 | HNF4A | HNF4A_HUMAN | NR2A1 | TCF14 | hepatocyte nuclear factor 4-alpha isoform b
Type:
PROTEIN
Mol. Mass.:
52790.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_606516
Residue:
474
Sequence:
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
  
Inhibitor
Name:
BDBM94587
Synonyms:
1-[1-(1H-benzimidazol-2-yl)-3-phenyl-propyl]-3-(2-furyl)quinoxalin-2-one | 1-[1-(1H-benzimidazol-2-yl)-3-phenyl-propyl]-3-(furan-2-yl)quinoxalin-2-one | 1-[1-(1H-benzimidazol-2-yl)-3-phenylpropyl]-3-(2-furanyl)-2-quinoxalinone | 1-[1-(1H-benzimidazol-2-yl)-3-phenylpropyl]-3-(furan-2-yl)quinoxalin-2-one | MLS003675343 | SMR001921264 | cid_53383516
Type:
Small organic molecule
Emp. Form.:
C28H22N4O2
Mol. Mass.:
446.4999
SMILES:
O=c1c(nc2ccccc2n1C(CCc1ccccc1)c1nc2ccccc2[nH]1)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: