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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM67822
Substrate
n/a
IC50
18427±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM67822
Synonyms:
1-[2-(2,4-dichlorophenoxy)ethyl]-3-methyl-1,3-dihydro-2H-benzimidazol-2-one | 1-[2-(2,4-dichlorophenoxy)ethyl]-3-methyl-2-benzimidazolone | 1-[2-(2,4-dichlorophenoxy)ethyl]-3-methyl-benzimidazol-2-one | 1-[2-(2,4-dichlorophenoxy)ethyl]-3-methylbenzimidazol-2-one | 1-[2-[2,4-bis(chloranyl)phenoxy]ethyl]-3-methyl-benzimidazol-2-one | MLS000535113 | SMR000142546 | cid_748782
Type:
Small organic molecule
Emp. Form.:
C16H14Cl2N2O2
Mol. Mass.:
337.201
SMILES:
Cn1c2ccccc2n(CCOc2ccc(Cl)cc2Cl)c1=O
Structure:
Search PDB for entries with ligand similarity: