Reaction Details Report a problem with these data
Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95203
Substrate
n/a
IC50
20321±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95203
Synonyms:
(E)-3-[1-phenyl-3-(p-tolyl)pyrazol-4-yl]-N-thiazol-2-yl-acrylamide | (E)-3-[3-(4-methylphenyl)-1-phenyl-4-pyrazolyl]-N-(2-thiazolyl)-2-propenamide | (E)-3-[3-(4-methylphenyl)-1-phenyl-pyrazol-4-yl]-N-(1,3-thiazol-2-yl)prop-2-enamide | (E)-3-[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]-N-(1,3-thiazol-2-yl)prop-2-enamide | MLS000390717 | SMR000259755 | cid_2360937
Type:
Small organic molecule
Emp. Form.:
C22H18N4OS
Mol. Mass.:
386.47
SMILES:
Cc1ccc(cc1)-c1nn(cc1\C=C\C(=O)Nc1nccs1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: