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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM94673
Substrate
n/a
IC50
35588±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM94673
Synonyms:
5-bromanyl-N-(2-methoxy-5-nitro-phenyl)thiophene-2-carboxamide | 5-bromo-N-(2-methoxy-5-nitro-phenyl)thiophene-2-carboxamide | 5-bromo-N-(2-methoxy-5-nitrophenyl)-2-thiophenecarboxamide | 5-bromo-N-(2-methoxy-5-nitrophenyl)thiophene-2-carboxamide | MLS000684369 | SMR000295941 | cid_1247109
Type:
Small organic molecule
Emp. Form.:
C12H9BrN2O4S
Mol. Mass.:
357.18
SMILES:
COc1ccc(cc1NC(=O)c1ccc(Br)s1)[N+]([O-])=O
Structure:
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