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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM94697
Substrate
n/a
IC50
28492±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM94697
Synonyms:
2-(2-furanyl)-6-[2-oxo-2-(1-piperidinyl)ethoxy]-1-benzopyran-4-one | 2-(2-furyl)-6-(2-keto-2-piperidino-ethoxy)chromone | 2-(2-furyl)-6-[2-oxo-2-(1-piperidinyl)ethoxy]-4H-chromen-4-one | 2-(furan-2-yl)-6-(2-oxidanylidene-2-piperidin-1-yl-ethoxy)chromen-4-one | 2-(furan-2-yl)-6-(2-oxo-2-piperidin-1-ylethoxy)chromen-4-one | MLS000679810 | SMR000296655 | cid_1695907
Type:
Small organic molecule
Emp. Form.:
C20H19NO5
Mol. Mass.:
353.3686
SMILES:
O=C(COc1ccc2oc(cc(=O)c2c1)-c1ccco1)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: