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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM94686
Substrate
n/a
IC50
10341±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM94686
Synonyms:
MLS000687260 | N'-[(E)-(4-benzoxybenzylidene)amino]-N-(4-pyridylmethyl)oxamide | N'-[(E)-(4-phenylmethoxyphenyl)methylideneamino]-N-(pyridin-4-ylmethyl)ethanediamide | N'-[(E)-(4-phenylmethoxyphenyl)methylideneamino]-N-(pyridin-4-ylmethyl)oxamide | SMR000283966 | cid_9593463
Type:
Small organic molecule
Emp. Form.:
C22H20N4O3
Mol. Mass.:
388.4192
SMILES:
O=C(NCc1ccncc1)C(=O)N\N=C\c1ccc(OCc2ccccc2)cc1
Structure:
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