Reaction Details Report a problem with these data
Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95208
Substrate
n/a
IC50
17816±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95208
Synonyms:
2-(5-amino-1-tetrazolyl)-N-[(E)-[5-(2,5-dimethyl-4-nitrophenyl)-2-furanyl]methylideneamino]acetamide | 2-(5-aminotetrazol-1-yl)-N-[(E)-[5-(2,5-dimethyl-4-nitro-phenyl)-2-furyl]methyleneamino]acetamide | 2-(5-aminotetrazol-1-yl)-N-[(E)-[5-(2,5-dimethyl-4-nitrophenyl)furan-2-yl]methylideneamino]acetamide | 2-(5-azanyl-1,2,3,4-tetrazol-1-yl)-N-[(E)-[5-(2,5-dimethyl-4-nitro-phenyl)furan-2-yl]methylideneamino]ethanamide | MLS000711597 | SMR000281364 | cid_9591176
Type:
Small organic molecule
Emp. Form.:
C16H16N8O4
Mol. Mass.:
384.3494
SMILES:
Cc1cc(c(C)cc1-c1ccc(\C=N\NC(=O)Cn2nnnc2N)o1)[N+]([O-])=O
Structure:
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