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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95209
Substrate
n/a
IC50
40729±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95209
Synonyms:
MLS000687875 | N-[4-[2-[[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2,3,4-tetrazol-5-yl]sulfanyl]ethanoylamino]phenyl]propanamide | N-[4-[[2-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)tetrazol-5-yl]sulfanylacetyl]amino]phenyl]propanamide | N-[4-[[2-[[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-tetrazolyl]thio]-1-oxoethyl]amino]phenyl]propanamide | N-[4-[[2-[[1-(2,3-dihydro-1,4-benzodioxin-6-yl)tetrazol-5-yl]thio]acetyl]amino]phenyl]propionamide | SMR000284852 | cid_1175754
Type:
Small organic molecule
Emp. Form.:
C20H20N6O4S
Mol. Mass.:
440.476
SMILES:
CCC(=O)Nc1ccc(NC(=O)CSc2nnnn2-c2ccc3OCCOc3c2)cc1
Structure:
Search PDB for entries with ligand similarity: