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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95218
Substrate
n/a
IC50
53071±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95218
Synonyms:
5-amino-N-(3-chloro-4-fluoro-phenyl)-1-[2-keto-2-(p-anisidino)ethyl]triazole-4-carboxamide | 5-amino-N-(3-chloro-4-fluorophenyl)-1-[2-(4-methoxyanilino)-2-oxoethyl]-4-triazolecarboxamide | 5-amino-N-(3-chloro-4-fluorophenyl)-1-[2-(4-methoxyanilino)-2-oxoethyl]triazole-4-carboxamide | 5-azanyl-N-(3-chloranyl-4-fluoranyl-phenyl)-1-[2-[(4-methoxyphenyl)amino]-2-oxidanylidene-ethyl]-1,2,3-triazole-4-carboxamide | MLS001116566 | SMR000630069 | cid_20923757
Type:
Small organic molecule
Emp. Form.:
C18H16ClFN6O3
Mol. Mass.:
418.809
SMILES:
COc1ccc(NC(=O)Cn2nnc(C(=O)Nc3ccc(F)c(Cl)c3)c2N)cc1
Structure:
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