Reaction Details
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ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95221
Substrate
n/a
IC50
50713±n/a nM
Citation
PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
Inhibitor
Name:
BDBM95221
Synonyms:
(5Z)-3-(4-chlorophenyl)-2,1-benzoxazole-5-carboxaldehyde oxime | (5Z)-3-(4-chlorophenyl)anthranil-5-carbaldehyde oxime | (NZ)-N-[[3-(4-chlorophenyl)-2,1-benzoxazol-5-yl]methylidene]hydroxylamine | 3-(4-chlorophenyl)-2,1-benzisoxazole-5-carbaldehyde oxime | MLS001166493 | SMR000549694 | cid_5524736
Type:
Small organic molecule
Emp. Form.:
C14H9ClN2O2
Mol. Mass.:
272.686
SMILES:
Clc1ccc(cc1)-c1onc2ccc(CN=O)cc12
Structure:
