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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM94665
Substrate
n/a
IC50
12352±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM94665
Synonyms:
MLS001230224 | N-[(Z)-[4-methoxy-3-[(2,3,5,6-tetrafluorophenoxy)methyl]benzylidene]amino]-4-nitro-benzamide | N-[(Z)-[4-methoxy-3-[(2,3,5,6-tetrafluorophenoxy)methyl]phenyl]methylideneamino]-4-nitrobenzamide | N-[(Z)-[4-methoxy-3-[[2,3,5,6-tetrakis(fluoranyl)phenoxy]methyl]phenyl]methylideneamino]-4-nitro-benzamide | SMR000678732 | cid_25237169
Type:
Small organic molecule
Emp. Form.:
C22H15F4N3O5
Mol. Mass.:
477.3652
SMILES:
COc1ccc([CH+][N-]NC(=O)c2ccc(cc2)[N+]([O-])=O)cc1COc1c(F)c(F)cc(F)c1F
Structure:
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