Reaction Details
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ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95225
Substrate
n/a
IC50
34496±n/a nM
Citation
PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
Inhibitor
Name:
BDBM95225
Synonyms:
1-(3,4-dimethylphenyl)-3-[2-(4-nitrophenoxy)ethanoylamino]urea | 1-(3,4-dimethylphenyl)-3-[[2-(4-nitrophenoxy)-1-oxoethyl]amino]urea | 1-(3,4-dimethylphenyl)-3-[[2-(4-nitrophenoxy)acetyl]amino]urea | MLS001232466 | SMR000679243 | cid_24818752
Type:
Small organic molecule
Emp. Form.:
C17H18N4O5
Mol. Mass.:
358.3486
SMILES:
Cc1ccc(NC(=O)NNC(=O)COc2ccc(cc2)[N+]([O-])=O)cc1C
Structure:
