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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95228
Substrate
n/a
IC50
53210±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95228
Synonyms:
4-[2-[(4-keto-7-methyl-pyrido[1,2-a][1,3,5]triazin-2-yl)thio]acetyl]piperazine-1-carboxylic acid ethyl ester | 4-[2-[(7-methyl-4-oxo-2-pyrido[1,2-a][1,3,5]triazinyl)thio]-1-oxoethyl]-1-piperazinecarboxylic acid ethyl ester | MLS001234952 | SMR000808699 | cid_7256702 | ethyl 4-[2-(7-methyl-4-oxidanylidene-pyrido[1,2-a][1,3,5]triazin-2-yl)sulfanylethanoyl]piperazine-1-carboxylate | ethyl 4-[2-(7-methyl-4-oxopyrido[1,2-a][1,3,5]triazin-2-yl)sulfanylacetyl]piperazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H21N5O4S
Mol. Mass.:
391.445
SMILES:
CCOC(=O)N1CCN(CC1)C(=O)CSc1nc2ccc(C)cn2c(=O)n1
Structure:
Search PDB for entries with ligand similarity: