Reaction Details
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Mitochondrial peptide methionine sulfoxide reductase
Ligand
BDBM47968
Substrate
n/a
IC50
14265±n/a nM
Citation
PubChem, PC Absorbance-based biochemical high throughput dose response assay to identify inhibitors of Methionine sulfoxide reductase A (MsrA) PubChem Bioassay (2013)[AID] More Info.:
Target
Name:
Mitochondrial peptide methionine sulfoxide reductase
Synonyms:
MSRA | MSRA protein | MSRA_BOVIN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25822.90
Organism:
Bos taurus
Description:
gi_73586699
Residue:
233
Sequence:
MLSATRRALQLFHSLFPIPRMGDSAAKIVSPQEALPGRKEPLVVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWTLKGVYSTQVGFAGGYTPNPTYKEVCSGKTGHAEVVRVVFQPEHISFEELLKVFWENHDPTQGMRQGNDHGSQYRSAIYPTSAEHVGAALKSKEDYQKVLSEHGFGLITTDIREGQTFYYAEDYHQQYLSKDPDGYCGLGGTGVSCPLGIKK
Inhibitor
Name:
BDBM47968
Synonyms:
MLS000686315 | N-[4-({(4Z)-1-oxo-4-[(thien-2-ylsulfonyl)imino]-1,4-dihydronaphthalen-2-yl}amino)phenyl]acetamide | N-[4-[(1-oxidanylidene-4-thiophen-2-ylsulfonylimino-naphthalen-2-yl)amino]phenyl]ethanamide | N-[4-[(1-oxo-4-thiophen-2-ylsulfonylimino-2-naphthalenyl)amino]phenyl]acetamide | N-[4-[(1-oxo-4-thiophen-2-ylsulfonyliminonaphthalen-2-yl)amino]phenyl]acetamide | N-[4-[[(4Z)-1-keto-4-(2-thienylsulfonylimino)-2-naphthyl]amino]phenyl]acetamide | N-[4-[[1-keto-4-(2-thienylsulfonylimino)-2-naphthyl]amino]phenyl]acetamide | SMR000313158 | cid_3715121
Type:
Small organic molecule
Emp. Form.:
C22H17N3O4S2
Mol. Mass.:
451.518
SMILES:
CC(=O)Nc1ccc(NC2=CC(=NS(=O)(=O)c3cccs3)c3ccccc3C2=O)cc1 |w:12.12,t:9|
Structure:
