Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 5 group A member 2
Ligand
BDBM95538
Substrate
n/a
IC50
143.49±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) PubChem Bioassay (2013)[AID] 
Target
Name:
Nuclear receptor subfamily 5 group A member 2
Synonyms:
Alpha-1-fetoprotein transcription factor | B1-binding factor | B1F | CPF | CYP7A promoter-binding factor | FTF | Hepatocytic transcription factor | LRH-1 | Liver Receptor Homolog 1 | NR5A2 | NR5A2_HUMAN | Nuclear receptor subfamily 5 group A member 2 | hB1F | nuclear receptor subfamily 5 group A member 2 isoform 2
Type:
Nuclear Hormone Receptor
Mol. Mass.:
61341.37
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
541
Sequence:
MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA
  
Inhibitor
Name:
BDBM95538
Synonyms:
3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid [(Z)-[amino-(5-nitro-2-furyl)methylene]amino] ester | 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxylic acid [(Z)-[amino-(5-nitro-2-furanyl)methylidene]amino] ester | MLS000861279 | O2-{[3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl]carbonyl}-5-nitrofuran-2-carbohydroximamide | SMR000460063 | [(Z)-[amino-(5-nitrofuran-2-yl)methylidene]amino] 3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylate | [(Z)-[azanyl-(5-nitrofuran-2-yl)methylidene]amino] 3-(2-chloranyl-6-fluoranyl-phenyl)-5-methyl-1,2-oxazole-4-carboxylate | cid_9566278
Type:
Small organic molecule
Emp. Form.:
C16H10ClFN4O6
Mol. Mass.:
408.725
SMILES:
Cc1onc(c1C(=O)O[N-]C(=[NH2+])c1ccc(o1)[N+]([O-])=O)-c1c(F)cccc1Cl |(7.42,3.85,;6.52,2.6,;4.98,2.6,;4.5,1.14,;5.75,.23,;6.99,1.14,;8.46,.66,;9.49,-.48,;9.6,1.69,;11.07,1.21,;12.21,2.24,;11.89,3.75,;13.68,1.77,;14.15,.3,;15.69,.3,;16.17,1.77,;14.92,2.67,;17.63,2.24,;18.78,1.21,;17.95,3.75,;5.75,-1.31,;7.08,-2.08,;8.62,-2.08,;7.08,-3.62,;5.75,-4.39,;4.41,-3.62,;4.41,-2.08,;3.08,-1.31,)|
Structure:
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