Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 5 group A member 2
Ligand
BDBM95539
Substrate
n/a
IC50
197.93±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) PubChem Bioassay (2013)[AID] 
Target
Name:
Nuclear receptor subfamily 5 group A member 2
Synonyms:
Alpha-1-fetoprotein transcription factor | B1-binding factor | B1F | CPF | CYP7A promoter-binding factor | FTF | Hepatocytic transcription factor | LRH-1 | Liver Receptor Homolog 1 | NR5A2 | NR5A2_HUMAN | Nuclear receptor subfamily 5 group A member 2 | hB1F | nuclear receptor subfamily 5 group A member 2 isoform 2
Type:
Nuclear Hormone Receptor
Mol. Mass.:
61341.37
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
541
Sequence:
MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA
  
Inhibitor
Name:
BDBM95539
Synonyms:
3-(2,3-dichlorophenyl)-5-methyl-4-isoxazolecarboxylic acid [(Z)-[amino-(5-nitro-2-furanyl)methylidene]amino] ester | 3-(2,3-dichlorophenyl)-5-methyl-isoxazole-4-carboxylic acid [(Z)-[amino-(5-nitro-2-furyl)methylene]amino] ester | MLS000861280 | O2-{[3-(2,3-dichlorophenyl)-5-methylisoxazol-4-yl]carbonyl}-5-nitrofuran-2-carbohydroximamide | SMR000460064 | [(Z)-[amino-(5-nitrofuran-2-yl)methylidene]amino] 3-(2,3-dichlorophenyl)-5-methyl-1,2-oxazole-4-carboxylate | [(Z)-[azanyl-(5-nitrofuran-2-yl)methylidene]amino] 3-[2,3-bis(chloranyl)phenyl]-5-methyl-1,2-oxazole-4-carboxylate | cid_9566279
Type:
Small organic molecule
Emp. Form.:
C16H10Cl2N4O6
Mol. Mass.:
425.18
SMILES:
Cc1onc(c1C(=O)O[N-]C(=[NH2+])c1ccc(o1)[N+]([O-])=O)-c1cccc(Cl)c1Cl
Structure:
Search PDB for entries with ligand similarity: