Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM68466
Substrate
n/a
IC50
>35871±n/a nM
Citation
 PubChem, PC Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2013)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM68466
Synonyms:
2-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]-N-(4-bromophenyl)ethanamide | MLS000057808 | N-(4-bromophenyl)-2-(2,5-dioxo-1-pyrrolidinyl)acetamide | N-(4-bromophenyl)-2-(2,5-dioxopyrrolidin-1-yl)acetamide | N-(4-bromophenyl)-2-succinimido-acetamide | SMR000063192 | cid_2083990
Type:
Small organic molecule
Emp. Form.:
C12H11BrN2O3
Mol. Mass.:
311.131
SMILES:
Brc1ccc(NC(=O)CN2C(=O)CCC2=O)cc1
Structure:
Search PDB for entries with ligand similarity: