Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM95481
Substrate
n/a
IC50
>35874±n/a nM
Citation
 PubChem, PC Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2013)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM95481
Synonyms:
1-[(1-tert-amyltetrazol-5-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperidin-4-ol | 1-[1-(1,1-Dimethyl-propyl)-1H-tetrazol-5-ylmethyl]-4-(3-trifluoromethyl-phenyl)-piperidin-4-ol | 1-[[1-(2-methylbutan-2-yl)-1,2,3,4-tetrazol-5-yl]methyl]-4-[3-(trifluoromethyl)phenyl]piperidin-4-ol | 1-[[1-(2-methylbutan-2-yl)-5-tetrazolyl]methyl]-4-[3-(trifluoromethyl)phenyl]-4-piperidinol | 1-[[1-(2-methylbutan-2-yl)tetrazol-5-yl]methyl]-4-[3-(trifluoromethyl)phenyl]piperidin-4-ol | MLS000528537 | SMR000121112 | cid_3228813
Type:
Small organic molecule
Emp. Form.:
C19H26F3N5O
Mol. Mass.:
397.4378
SMILES:
CCC(C)(C)n1nnnc1CN1CCC(O)(CC1)c1cccc(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: