Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM95918
Substrate
n/a
EC50
5430±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM95918
Synonyms:
(1-Methyl-1H-benzoimidazol-2-yl)-(4-methyl-benzyl)-amine | (1-methylbenzimidazol-2-yl)-(4-methylbenzyl)amine | 1-methyl-N-[(4-methylphenyl)methyl]-2-benzimidazolamine | 1-methyl-N-[(4-methylphenyl)methyl]benzimidazol-2-amine | MLS001206102 | SMR000524108 | cid_1090102
Type:
Small organic molecule
Emp. Form.:
C16H17N3
Mol. Mass.:
251.3263
SMILES:
Cc1ccc(CNc2nc3ccccc3n2C)cc1
Structure:
Search PDB for entries with ligand similarity: