Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM95929
Substrate
n/a
EC50
9580±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM95929
Synonyms:
MLS000689044 | N-[(E)-[(Z)-2-chloranyl-3-phenyl-prop-2-enylidene]amino]pyridine-2-carboxamide | N-[(E)-[(Z)-2-chloro-3-phenyl-prop-2-enylidene]amino]picolinamide | N-[(E)-[(Z)-2-chloro-3-phenylprop-2-enylidene]amino]-2-pyridinecarboxamide | N-[(E)-[(Z)-2-chloro-3-phenylprop-2-enylidene]amino]pyridine-2-carboxamide | SMR000283202 | cid_5761101
Type:
Small organic molecule
Emp. Form.:
C15H12ClN3O
Mol. Mass.:
285.728
SMILES:
Cl\C(\C=N\NC(=O)c1ccccn1)=C/c1ccccc1
Structure:
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