Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM95951
Substrate
n/a
EC50
>12500±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM95951
Synonyms:
1,4,5,6-Tetrahydro-cyclopentapyrazole-3-carboxylic acid [1-furan-2-yl-eth-(E)-ylidene]-hydrazide | MLS000768977 | N-[(E)-1-(2-furanyl)ethylideneamino]-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide | N-[(E)-1-(2-furyl)ethylideneamino]-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide | N-[(E)-1-(furan-2-yl)ethylideneamino]-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide | SMR000433711 | cid_5396929
Type:
Small organic molecule
Emp. Form.:
C13H14N4O2
Mol. Mass.:
258.2759
SMILES:
CC(=NNC(=O)c1[nH]nc2CCCc12)c1ccco1 |w:2.2|
Structure:
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